Omadacycline for Community-Acquired Bacterial Pneumonia

Bacterial Pathogens Associated with Community acquired Pneumonia.

2. The use of oropharyngeal aspirate as the sample for isolation of bacterial pathogens associated with community acquired pneumonia (CAP) raises many questions. This is again highlighted by the isolation of organism like Acinetobacter and Citrobacter species from CAP cases. The value of isolating bacterial organisms that are frequently detected in the upper airways of children (eg, Streptococc...

Ceftaroline: A Therapeutic Option for Community-Acquired Bacterial Pneumonia

On October 29, 2010, the U.S. FDA approved ceftaroline fosamil, a new cephalosporin with extended Gram positive coverage, for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia (CABP). Unlike the currently available cephalosporins, ceftaroline maintains bactericidal activity against multi-drug resistant Gram positive pathogens like MRS...

Doxycycline for community-acquired pneumonia.

Sir—I read with interest the article by Johnson [1] suggesting a more prominent role for doxycycline in empiric therapy for community-acquired pneumonia (CAP). A response by Lederman et al. [2] described an in vitro susceptibility survey that compared tetracycline with doxycy-cline against bacterial pathogens causing CAP. The survey emphasized the relative lack of susceptibility of Streptococcu...

Corticosteroids for Community-Acquired Pneumonia.

Antibiotics for community-acquired pneumonia.

Antibiotic guidelines for community-acquired pneumonia (CAP) often recommend broad-spectrum agents for severe pneumonia. While these may be entirely appropriate in terms of their spectrum of activity and efficacy, there is a risk that such recommendations could result in over-prescribing of broad-spectrum agents with consequent 'collateral damage', meaning superinfection by resistant pathogens,...